androstenediol (3beta,17beta) monosulfate (1) to androsterone glucuronide

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (1)
Metabolite Accession: GCST90199872
Name: androstenediol (3beta,17beta) monosulfate (1)
Hmdb Id: HMDB0240429
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.251
Position:
48374950
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
-12.967
Reference Allele:
C
-log10(P):
-86.867
MAF:
0.161
Beta (Num):
-0.081
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Androgen steroid sulfonation

Denominator Metabolite Explanation:

Androgen steroid glucuronidation

Ratio Explanation:

The ratio reflects competing metabolic fates of androgens; a higher ratio indicates a preference for sulfonation (SULT2A1 activity) over glucuronidation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 are linked to cholelithiasis.4[1], 5[2] SULT2A1's role in sulfonating bile acids and steroids can alter bile composition and increase gallstone risk, with this ratio reflecting altered steroid metabolism that is seen alongside the phenotype.1[3], 6[4]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data