androstenediol (3beta,17beta) disulfate (2) to androsterone glucuronide

Numerator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (2)
Metabolite Accession: GCST90199851
Name: androstenediol (3beta,17beta) disulfate (2)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs4149056

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
12
Beta (Ratio):
0.252
Position:
21331549
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
13.122
Reference Allele:
T
-log10(P):
-88.899
MAF:
0.156
Beta (Num):
0.210
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.041
SE (Den):
0.018
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
19
Beta (Ratio):
-0.226
Position:
48374950
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
-11.806
Reference Allele:
C
-log10(P):
-72.390
MAF:
0.161
Beta (Num):
-0.056
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Androgen metabolism, steroid sulfation.2[1], 3[2]

Denominator Metabolite Explanation:

Androgen metabolism, steroid glucuronidation.4[1], 5[2]

Ratio Explanation:

This ratio contrasts androgen elimination through sulfation, mediated by SULT2A1, versus glucuronidation, reflecting the activity of the SULT2A1 enzyme on androgen precursors.1[1], 5[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

SULT2A1 gene activity influences the metabolism of both sex steroids, reflected in the ratio, and bile acids; altered bile acid sulfation is a known risk factor for cholelithiasis.6[1], 7[2], 8[3]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data