taurodeoxycholic acid 3-sulfate to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2)

Numerator Metabolite

Metabolite Accession: GCST90200024
Name: taurodeoxycholic acid 3-sulfate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90199854
Name: 5alpha-pregnan-3beta,20alpha-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs62129966

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.306
Position:
48374950
SE (Ratio):
0.031
Effect Allele:
A
Z-score (Ratio):
-9.967
Reference Allele:
C
-log10(P):
-52.201
MAF:
0.156
Beta (Num):
-0.142
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
0.163
SE (Den):
0.021
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Bile acid metabolism

Denominator Metabolite Explanation:

Steroid hormone biosynthesis

Ratio Explanation:

This ratio reflects the sulfation activity of SULT2A1, comparing its action on bile acids versus steroids, thus indicating shifts in detoxification pathways.1[1], 2[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 alter its enzymatic activity, impacting the balance of sulfated bile acids and steroids.2[1], 4[2] An altered ratio reflects changes in bile acid composition, a key factor in cholelithiasis development, linking the gene to the phenotype.5[3], 4[4], 6[5]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data