lithocholate sulfate (1) to androsterone glucuronide

Numerator Metabolite

Metabolite Accession: GCST90200231
Name: lithocholate sulfate (1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.393
Position:
48374950
SE (Ratio):
0.028
Effect Allele:
A
Z-score (Ratio):
-14.192
Reference Allele:
C
-log10(P):
-103.596
MAF:
0.160
Beta (Num):
-0.223
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Bile Acid Metabolism, Bile Acid Sulfation.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Steroid Metabolism, Androgen Glucuronidation.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio may reflect the relative activity of sulfation by SULT2A1 versus glucuronidation pathways for steroid and bile acid detoxification.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in SULT2A1 alters its function in detoxifying toxic bile acids, such as lithocholate, by sulfation.9[1], 1[2], 10[3] This dysregulation, reflected by the ratio, is associated with cholelithiasis (gallstones), cholecystitis, and elevated alkaline phosphatase levels.9[4], 11[5]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data