metabolonic lactone sulfate to androsterone glucuronide

Numerator Metabolite

Metabolite Accession: GCST90200257
Name: metabolonic lactone sulfate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62129966

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.331
Position:
48374950
SE (Ratio):
0.026
Effect Allele:
A
Z-score (Ratio):
-12.654
Reference Allele:
C
-log10(P):
-82.833
MAF:
0.161
Beta (Num):
-0.161
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Steroid sulfation

Denominator Metabolite Explanation:

Steroid glucuronidation

Ratio Explanation:

The ratio reflects the balance between sulfation and glucuronidation of steroids; a higher ratio indicates increased SULT2A1-mediated sulfation relative to glucuronidation.2[1], 3[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SULT2A1 activity, indicated by the ratio, likely disrupts steroid and bile acid metabolism homeostasis in the liver.1[1], 2[2] This dysregulation can alter bile composition, increasing the risk of cholesterol gallstone formation (cholelithiasis) and subsequent gallbladder inflammation (cholecystitis).1[3], 4[4]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data