pregnanediol-3-glucuronide to DHEAS

Numerator Metabolite

Structure of pregnanediol-3-glucuronide
Metabolite Accession: GCST90199917
Name: pregnanediol-3-glucuronide
Hmdb Id: HMDB0010318
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZFFFJLDTCLJDHL

Denominator Metabolite

Structure of dehydroepiandrosterone sulfate (dhea-s)
Metabolite Accession: GCST90199673
Name: dehydroepiandrosterone sulfate (dhea-s)
Hmdb Id: HMDB0001032
Super Pathway: NA
Sub Pathway: NA
Inchikey: CZWCKYRVOZZJNM

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.196
Position:
48374950
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
9.029
Reference Allele:
C
-log10(P):
-43.203
MAF:
0.162
Beta (Num):
0.112
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
-0.085
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis, Progesterone metabolism

Denominator Metabolite Explanation:

Steroidogenesis, Androgen and estrogen metabolism

Ratio Explanation:

The ratio of pregnanediol-3-glucuronide to DHEAS may reflect the balance between progesterone metabolism and DHEA sulfation, which is catalyzed by SULT2A1.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 are associated with altered SULT2A1 activity and an increased risk of cholelithiasis.3[1], 4[2], 5[3] Dysregulation of bile acid and steroid sulfation by SULT2A1 can contribute to the formation of gallstones.3[4], 6[5]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data