pregnanediol-3-glucuronide to 21-hydroxypregnenolone disulfate

Numerator Metabolite

Structure of pregnanediol-3-glucuronide
Metabolite Accession: GCST90199917
Name: pregnanediol-3-glucuronide
Hmdb Id: HMDB0010318
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZFFFJLDTCLJDHL

Denominator Metabolite

Structure of 21-hydroxypregnenolone disulfate
Metabolite Accession: GCST90199849
Name: 21-hydroxypregnenolone disulfate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBOVWLYQUCVTFA

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.270
Position:
48374950
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
13.050
Reference Allele:
C
-log10(P):
-87.949
MAF:
0.162
Beta (Num):
0.112
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.159
SE (Den):
0.020
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Progesterone metabolism6[1]

Denominator Metabolite Explanation:

Steroidogenesis7[1]

Ratio Explanation:

The ratio reflects SULT2A1 activity; higher values may indicate increased progesterone metabolism relative to pregnenolone sulfation, potentially altering bile acid composition.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Lower SULT2A1 activity can decrease the sulfation and excretion of steroid metabolites, including those related to bile acids, potentially contributing to cholelithiasis.3[1], 4[2], 8[3]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data