androstenediol (3beta,17beta) monosulfate (2) to androsterone glucuronide

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.257
Position:
48374950
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
-11.983
Reference Allele:
C
-log10(P):
-74.506
MAF:
0.162
Beta (Num):
-0.087
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Androgen steroidogenesis

Denominator Metabolite Explanation:

Androgen steroidogenesis, Glucuronidation4[1], 5[2], 6[3]

Ratio Explanation:

This ratio reflects the balance between two major steroid conjugation pathways: sulfation, influenced by SULT2A1, and glucuronidation, affecting clearance of different androgen metabolites.1[1], 4[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic evidence strongly links SULT2A1 to cholelithiasis.7[1], 8[2], 9[3] Altered SULT2A1 activity likely changes steroid and bile acid sulfation, affecting bile composition and increasing gallstone risk, a process reflected by the metabolic ratio and associated with cholecystitis and elevated ALP.7[4], 10[5], 11[6]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data