androstenediol (3beta,17beta) disulfate (1) to androsterone glucuronide

Numerator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (1)
Metabolite Accession: GCST90199842
Name: androstenediol (3beta,17beta) disulfate (1)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.569
Position:
48374950
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
-26.107
Reference Allele:
C
-log10(P):
-344.265
MAF:
0.160
Beta (Num):
-0.399
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Steroid sulfation.3[1]

Denominator Metabolite Explanation:

Steroid glucuronidation.4[1], 5[2]

Ratio Explanation:

The ratio reflects the balance between sulfation (numerator) and glucuronidation (denominator) of androgens, with SULT2A1 activity influencing sulfated androgen levels.1[1], 6[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in SULT2A1 alters steroid metabolism.7[1], 8[2] Since steroid hormones influence bile composition, this altered metabolism can increase susceptibility to cholelithiasis (gallstone disease) and associated conditions like cholecystitis.7[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data