glycoursodeoxycholic acid sulfate (1) to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2)

Numerator Metabolite

Structure of glycoursodeoxycholic acid sulfate (1)
Metabolite Accession: GCST90200221
Name: glycoursodeoxycholic acid sulfate (1)
Hmdb Id: HMDB0002409
Super Pathway: NA
Sub Pathway: NA
Inchikey: DKXXSIJHWWVNMO

Denominator Metabolite

Metabolite Accession: GCST90199854
Name: 5alpha-pregnan-3beta,20alpha-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.352
Position:
48374950
SE (Ratio):
0.033
Effect Allele:
A
Z-score (Ratio):
-10.551
Reference Allele:
C
-log10(P):
-58.249
MAF:
0.150
Beta (Num):
-0.188
Novel Locus:
No
SE (Num):
0.024
Beta (Den):
0.163
SE (Den):
0.021
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Bile acid metabolism6[1], 7[2]

Denominator Metabolite Explanation:

Steroid hormone biosynthesis8[1], 9[2]

Ratio Explanation:

The ratio reflects the relative activity of SULT2A1 in sulfating bile acids versus steroids, which are competing substrates for the enzyme.2[1], 10[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SULT2A1 activity likely changes the composition of bile acids, a known risk factor for cholelithiasis.6[1], 11[2], 4[3] This altered sulfation balance between bile acids and steroids, driven by SULT2A1 genetics, contributes to gallstone formation and gallbladder inflammation.5[4], 12[5]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data