taurodeoxycholic acid 3-sulfate to 3b-hydroxy-5-cholenoic acid

Numerator Metabolite

Metabolite Accession: GCST90200024
Name: taurodeoxycholic acid 3-sulfate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3b-hydroxy-5-cholenoic acid
Metabolite Accession: GCST90199933
Name: 3b-hydroxy-5-cholenoic acid
Hmdb Id: HMDB0000308
Super Pathway: NA
Sub Pathway: NA
Inchikey: HIAJCGFYHIANNA

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.304
Position:
48374950
SE (Ratio):
0.031
Effect Allele:
A
Z-score (Ratio):
-9.669
Reference Allele:
C
-log10(P):
-49.248
MAF:
0.156
Beta (Num):
-0.142
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
0.161
SE (Den):
0.023
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Secondary bile acid sulfation.

Denominator Metabolite Explanation:

Alternative bile acid synthesis.

Ratio Explanation:

The ratio reflects SULT2A1 activity, with a higher value indicating greater sulfation of a secondary bile acid (numerator) relative to a primary precursor (denominator).4[1], 5[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 alter bile acid sulfation, which can change bile composition and solubility.1[1], 6[2], 7[3] This metabolic shift is a known risk factor for developing cholelithiasis (gallstones) and associated biliary complications like cholecystitis.8[4], 9[5], 10[6]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data