glycochenodeoxycholate 3-sulfate to androsterone glucuronide

Numerator Metabolite

Structure of glycochenodeoxycholate 3-sulfate
Metabolite Accession: GCST90200022
Name: glycochenodeoxycholate 3-sulfate
Hmdb Id: HMDB0002409,HMDB0002497
Super Pathway: NA
Sub Pathway: NA
Inchikey: DKXXSIJHWWVNMO

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.473
Position:
48374950
SE (Ratio):
0.028
Effect Allele:
A
Z-score (Ratio):
-16.716
Reference Allele:
C
-log10(P):
-142.762
MAF:
0.160
Beta (Num):
-0.303
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Bile acid biosynthesis/metabolism.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Steroid hormone biosynthesis.9[1], 10[2]

Ratio Explanation:

This ratio reflects SULT2A1 activity, which produces the numerator (sulfated bile acid) and metabolizes precursors related to the denominator (a glucuronidated steroid).1[1], 3[2], 9[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 alter its function in sulfating bile acids, a process critical for their detoxification and elimination.1[1], 11[2] This altered metabolism, reflected by the ratio, contributes to bile acid dysregulation, a known mechanism for cholelithiasis (gallstone disease) and associated inflammation.11[3], 4[4], 5[5]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data