taurochenodeoxycholic acid 3-sulfate to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2)

Numerator Metabolite

Structure of taurochenodeoxycholic acid 3-sulfate
Metabolite Accession: GCST90200242
Name: taurochenodeoxycholic acid 3-sulfate
Hmdb Id: HMDB0002486
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJHJZQKOSUFQCX

Denominator Metabolite

Metabolite Accession: GCST90199854
Name: 5alpha-pregnan-3beta,20alpha-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.351
Position:
48374950
SE (Ratio):
0.032
Effect Allele:
A
Z-score (Ratio):
-11.002
Reference Allele:
C
-log10(P):
-63.157
MAF:
0.155
Beta (Num):
-0.188
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
0.163
SE (Den):
0.021
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Bile acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Steroid hormone biosynthesis.6[1], 7[2]

Ratio Explanation:

The ratio reflects SULT2A1's competing sulfation activity on bile acids versus pregnane steroids, as the enzyme catalyzes the sulfation of both compounds.8[1], 4[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SULT2A1 activity can alter bile acid metabolism, a key factor in cholelithiasis (gallstone disease).9[1], 10[2], 11[3] Genetic variants in SULT2A1 are linked to an increased risk of cholelithiasis, likely by impairing bile acid sulfation and detoxification, leading to stone formation.10[4], 12[5]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data