androsterone glucuronide to androsterone sulfate

Numerator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Denominator Metabolite

Structure of androsterone sulfate
Metabolite Accession: GCST90200674
Name: androsterone sulfate
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs62129966

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.301
Position:
48374950
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
14.512
Reference Allele:
C
-log10(P):
-108.199
MAF:
0.162
Beta (Num):
0.170
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.130
SE (Den):
0.020
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

Region: rs9884390

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Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
0.248
Position:
69373407
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
13.326
Reference Allele:
T
-log10(P):
-91.614
MAF:
0.223
Beta (Num):
0.071
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.177
SE (Den):
0.018
No CNV overlap
rQTL cluster:
124
Reaction Distance:
NA
Closest Genes:
TMPRSS11E UGT2B17 UGT2B15 YTHDC1 TMPRSS11B

LLM Analysis

Numerator Metabolite Explanation:

Steroid hormone metabolism7[1], 8[2]

Denominator Metabolite Explanation:

Steroid hormone metabolism7[1], 5[2], 9[3]

Ratio Explanation:

The ratio of androsterone glucuronide to androsterone sulfate reflects the balance between glucuronidation by UGT enzymes and sulfation by SULT enzymes in androgen breakdown.7[1], 10[2], 11[3], 12[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1, which regulates sulfation of steroids and bile acids, are associated with the androsterone glucuronide to sulfate ratio and risk for cholelithiasis and hypercholesterolemia.1[1], 4[2], 13[3], 5[4], 14[5], 15[6], 16[7]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data