pregnanediol-3-glucuronide to 5alpha-pregnan-3beta,20beta-diol monosulfate (1)

Numerator Metabolite

Structure of pregnanediol-3-glucuronide
Metabolite Accession: GCST90199917
Name: pregnanediol-3-glucuronide
Hmdb Id: HMDB0010318
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZFFFJLDTCLJDHL

Denominator Metabolite

Structure of 5alpha-pregnan-3beta,20beta-diol monosulfate (1)
Metabolite Accession: GCST90199853
Name: 5alpha-pregnan-3beta,20beta-diol monosulfate (1)
Hmdb Id: HMDB0240580
Super Pathway: NA
Sub Pathway: NA
Inchikey: NOGKXXMAHGCQBS

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.170
Position:
48374950
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
9.134
Reference Allele:
C
-log10(P):
-44.162
MAF:
0.162
Beta (Num):
0.112
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
-0.058
SE (Den):
0.021
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Progesterone metabolism, Glucuronidation.6[1], 7[2], 8[3], 9[4], 10[5]

Denominator Metabolite Explanation:

Progesterone metabolism, Sulfation.11[1], 12[2], 13[3], 14[4], 15[5]

Ratio Explanation:

This ratio reflects the balance between glucuronidation and SULT2A1-mediated sulfation in progesterone metabolism; lower SULT2A1 activity likely increases the ratio.1[1], 6[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 alter steroid hormone sulfation, affecting the balance of pregnanediol conjugates.1[1], 4[2] This altered steroid profile is associated with cholelithiasis, likely by modifying bile composition and increasing the risk of gallstone formation.16[3], 17[4], 18[5], 19[6]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data