5alpha-androstan-3beta,17alpha-diol disulfate to androsterone glucuronide

Numerator Metabolite

Structure of 5alpha-androstan-3beta,17alpha-diol disulfate
Metabolite Accession: GCST90199852
Name: 5alpha-androstan-3beta,17alpha-diol disulfate
Hmdb Id: HMDB0094682
Super Pathway: NA
Sub Pathway: NA
Inchikey: JHFAETDERBWUOO

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.344
Position:
48374950
SE (Ratio):
0.025
Effect Allele:
A
Z-score (Ratio):
-13.792
Reference Allele:
C
-log10(P):
-97.971
MAF:
0.161
Beta (Num):
-0.174
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Androgen Metabolism

Denominator Metabolite Explanation:

Androgen Metabolism

Ratio Explanation:

The ratio reflects SULT2A1 activity, where higher values suggest increased sulfation of 5alpha-androstan-3beta,17alpha-diol relative to the glucuronidation of androsterone.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variations in SULT2A1 likely alter its enzymatic activity, affecting the balance of steroid hormone and bile acid metabolism. This dysregulation is a known risk factor for the development of cholelithiasis (gallstones), a condition linked to altered bile composition.2[1], 1[2], 3[3]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data