glycoursodeoxycholic acid sulfate (1) to androsterone glucuronide

Numerator Metabolite

Structure of glycoursodeoxycholic acid sulfate (1)
Metabolite Accession: GCST90200221
Name: glycoursodeoxycholic acid sulfate (1)
Hmdb Id: HMDB0002409
Super Pathway: NA
Sub Pathway: NA
Inchikey: DKXXSIJHWWVNMO

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.358
Position:
48374950
SE (Ratio):
0.031
Effect Allele:
A
Z-score (Ratio):
-11.717
Reference Allele:
C
-log10(P):
-71.334
MAF:
0.150
Beta (Num):
-0.188
Novel Locus:
No
SE (Num):
0.024
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Bile acid synthesis and sulfation.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Androgen and steroid metabolism (glucuronidation).9[1], 10[2], 11[3]

Ratio Explanation:

The ratio reflects the balance between sulfation of bile acids and glucuronidation of androgens, two major conjugation pathways catalyzed by SULT2A1 and UGT enzymes respectively.12[1], 9[2], 3[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 alter its enzymatic activity, impacting the sulfation of bile acids (numerator).12[1], 3[2] This dysregulation of bile acid metabolism is a known risk factor for cholelithiasis, a phenotype strongly associated with SULT2A1 variants.4[3], 13[4], 5[5]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data