lithocholate sulfate (1) to glycolithocholate

Numerator Metabolite

Metabolite Accession: GCST90200231
Name: lithocholate sulfate (1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of glycolithocholate
Metabolite Accession: GCST90199689
Name: glycolithocholate
Hmdb Id: HMDB00698
Super Pathway: NA
Sub Pathway: NA
Inchikey: XBSQTYHEGZTYJE

Associated Genomic Regions

Region: rs62129966

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.333
Position:
48374950
SE (Ratio):
0.026
Effect Allele:
A
Z-score (Ratio):
-12.769
Reference Allele:
C
-log10(P):
-84.305
MAF:
0.160
Beta (Num):
-0.223
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.110
SE (Den):
0.022
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Secondary bile acid sulfation.3[1], 4[2]

Denominator Metabolite Explanation:

Secondary bile acid conjugation.

Ratio Explanation:

The ratio reflects the activity of two competing detoxification pathways for lithocholate; a higher ratio indicates a preference for sulfation by SULT2A1 over glycine conjugation.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 influence its enzymatic activity, altering the balance of bile acid detoxification pathways.5[1], 6[2] This change in the lithocholate sulfate to glycolithocholate ratio is associated with an increased risk of cholelithiasis and cholecystitis, likely by affecting bile composition and promoting gallstone formation.7[3], 8[4]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data