5alpha-androstan-3beta,17beta-diol disulfate to 3b-hydroxy-5-cholenoic acid

Numerator Metabolite

Metabolite Accession: GCST90199835
Name: 5alpha-androstan-3beta,17beta-diol disulfate
Hmdb Id: HMDB00493
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3b-hydroxy-5-cholenoic acid
Metabolite Accession: GCST90199933
Name: 3b-hydroxy-5-cholenoic acid
Hmdb Id: HMDB0000308
Super Pathway: NA
Sub Pathway: NA
Inchikey: HIAJCGFYHIANNA

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
19
Beta (Ratio):
-0.299
Position:
48374950
SE (Ratio):
0.030
Effect Allele:
A
Z-score (Ratio):
-10.075
Reference Allele:
C
-log10(P):
-53.296
MAF:
0.160
Beta (Num):
-0.137
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.161
SE (Den):
0.023
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Androgen Metabolism

Denominator Metabolite Explanation:

Primary Bile Acid Biosynthesis

Ratio Explanation:

This ratio likely reflects SULT2A1 activity, which acts on precursors to the androgen numerator and on the bile acid denominator, influencing their balance.2[1]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in SULT2A1 alters its sulfation of steroids and bile acids, impacting bile composition as reflected by the ratio, and increasing risk for Cholelithiasis.3[1], 4[2], 5[3]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data