androstenediol (3alpha, 17alpha) monosulfate (3) to androsterone glucuronide

Numerator Metabolite

Metabolite Accession: GCST90199856
Name: androstenediol (3alpha, 17alpha) monosulfate (3)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62129966

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.504
Position:
48374950
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
-23.596
Reference Allele:
C
-log10(P):
-281.771
MAF:
0.160
Beta (Num):
-0.334
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

Region: rs35307342

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Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
0.246
Position:
69361389
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
14.445
Reference Allele:
T
-log10(P):
-107.226
MAF:
0.362
Beta (Num):
0.190
Novel Locus:
No
SE (Num):
0.014
Beta (Den):
-0.056
SE (Den):
0.014
No CNV overlap
rQTL cluster:
124
Reaction Distance:
NA
Closest Genes:
TMPRSS11E UGT2B17 YTHDC1 UGT2B15 TMPRSS11B

LLM Analysis

Numerator Metabolite Explanation:

Androgen sulfation

Denominator Metabolite Explanation:

Androgen glucuronidation

Ratio Explanation:

The ratio reflects the balance between two major androgen inactivation pathways, sulfation and glucuronidation, influenced by the enzymatic activities of SULT2A1 and UGT2B17.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 and UGT2B17 alter the balance of androgen metabolism.6[1], 7[2] This dysregulation, particularly the SULT2A1-driven changes in sulfation, affects bile acid and steroid homeostasis, contributing to cholelithiasis and disorders of lipoprotein metabolism.8[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data