deoxycholic acid 12-sulfate* to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2)

Numerator Metabolite

Metabolite Accession: GCST90200250
Name: deoxycholic acid 12-sulfate*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90199854
Name: 5alpha-pregnan-3beta,20alpha-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs2547233

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
19
Beta (Ratio):
-0.373
Position:
48384026
SE (Ratio):
0.030
Effect Allele:
A
Z-score (Ratio):
-12.365
Reference Allele:
G
-log10(P):
-79.193
MAF:
0.161
Beta (Num):
-0.210
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
0.163
SE (Den):
0.021
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 BSPH1

LLM Analysis

Numerator Metabolite Explanation:

Secondary bile acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Steroid hormone biosynthesis.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects SULT2A1's substrate preference, comparing sulfation of bile acids (numerator) against steroid hormones (denominator), indicating metabolic flux through these pathways.1[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in SULT2A1 alters the sulfation and metabolism of bile acids, affecting bile composition.10[1], 11[2], 12[3] This change, reflected by the ratio, is a plausible mechanism for increased cholelithiasis (gallstone) risk, a phenotype strongly associated with SULT2A1 variants and bile acid dysregulation.10[4], 11[5], 13[6], 14[7]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data