1-stearoyl-gpe (18:0) to 1-oleoyl-gpe (18:1)

Numerator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Denominator Metabolite

Structure of 1-oleoyl-gpe (18:1)
Metabolite Accession: GCST90199794
Name: 1-oleoyl-gpe (18:1)
Hmdb Id: HMDB0011506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PYVRVRFVLRNJLY

Associated Genomic Regions

Region: rs102275

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.152
Position:
61557803
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
-9.979
Reference Allele:
T
-log10(P):
-52.326
MAF:
0.346
Beta (Num):
-0.078
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.075
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

Region: rs4683709

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
3
Beta (Ratio):
-0.125
Position:
142653249
SE (Ratio):
0.015
Effect Allele:
T
Z-score (Ratio):
-8.263
Reference Allele:
G
-log10(P):
-36.489
MAF:
0.337
Beta (Num):
-0.036
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.089
SE (Den):
0.016
No CNV overlap
rQTL cluster:
132
Reaction Distance:
NA
Closest Genes:
PAQR9 U2SURP PCOLCE2 TRPC1 CHST2

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid metabolism.6[1], 7[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid metabolism.6[1], 8[2]

Ratio Explanation:

The ratio reflects the activity of stearoyl-CoA desaturase, influenced by FADS1, converting saturated to monounsaturated fatty acids, impacting membrane fluidity and signaling.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity, influenced by genetic factors, alters the balance of saturated and unsaturated fatty acids, contributing to dyslipidemia and inflammatory conditions like IBD and cholelithiasis.9[1], 10[2], 11[3], 12[4], 13[5], 14[6], 15[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data