1-linoleoyl-gpe (18:2)* to 1-oleoyl-gpe (18:1)

Numerator Metabolite

Structure of 1-linoleoyl-gpe (18:2)*
Metabolite Accession: GCST90199793
Name: 1-linoleoyl-gpe (18:2)*
Hmdb Id: HMDB0011507
Super Pathway: NA
Sub Pathway: NA
Inchikey: DBHKHNGBVGWQJE

Denominator Metabolite

Structure of 1-oleoyl-gpe (18:1)
Metabolite Accession: GCST90199794
Name: 1-oleoyl-gpe (18:1)
Hmdb Id: HMDB0011506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PYVRVRFVLRNJLY

Associated Genomic Regions

Region: rs174547

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.203
Position:
61570783
SE (Ratio):
0.010
Effect Allele:
C
Z-score (Ratio):
20.189
Reference Allele:
T
-log10(P):
-207.023
MAF:
0.339
Beta (Num):
0.283
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.080
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

Region: rs10212439

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Clumped rQTL variant

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SNP Summary

Chr:
3
Beta (Ratio):
0.095
Position:
142655053
SE (Ratio):
0.010
Effect Allele:
T
Z-score (Ratio):
9.806
Reference Allele:
C
-log10(P):
-50.601
MAF:
0.489
Beta (Num):
0.012
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.082
SE (Den):
0.015
No CNV overlap
rQTL cluster:
132
Reaction Distance:
NA
Closest Genes:
PAQR9 U2SURP PCOLCE2 TRPC1 CHST2

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid metabolism

Ratio Explanation:

The ratio of 1-linoleoyl-gpe (18:2) to 1-oleoyl-gpe (18:1) reflects the balance of different fatty acyl chains in lysophospholipids, influenced by FADS enzyme activity.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1 and FADS2 genes affect the metabolism of polyunsaturated fatty acids, influencing the ratio of 1-linoleoyl-gpe (18:2) to 1-oleoyl-gpe (18:1).2[1], 3[2] This altered lipid profile is associated with metabolic phenotypes like hypercholesterolemia, cholelithiasis, and type 2 diabetes.4[3], 5[4], 6[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data