1-oleoyl-gpe (18:1) to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of 1-oleoyl-gpe (18:1)
Metabolite Accession: GCST90199794
Name: 1-oleoyl-gpe (18:1)
Hmdb Id: HMDB0011506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PYVRVRFVLRNJLY

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs9848779

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
3
Beta (Ratio):
-0.101
Position:
142652069
SE (Ratio):
0.012
Effect Allele:
C
Z-score (Ratio):
-8.703
Reference Allele:
G
-log10(P):
-40.273
MAF:
0.469
Beta (Num):
-0.084
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
0.017
SE (Den):
0.015
No CNV overlap
rQTL cluster:
132
Reaction Distance:
NA
Closest Genes:
PAQR9 U2SURP PCOLCE2 TRPC1 CHST2

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

The ratio of 1-oleoyl-gpe (18:1) to 1-linoleoyl-gpc (18:2) reflects the balance between two classes of lysophospholipids, which are involved in lipid signaling and membrane composition.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

PAQR9 influences hepatic lipid metabolism by regulating fatty acid oxidation.1[1], 2[2] Altered PAQR9 function can lead to lipid accumulation, a key feature of lipoprotein metabolism disorders and a contributor to elevated ALT levels, indicating liver stress.1[3], 3[4], 4[5]

Phenotype Driver:

Gene-centric:PAQR9

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data