1-stearoyl-2-oleoyl-gpe (18:0/18:1) to 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)

Numerator Metabolite

Structure of 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Metabolite Accession: GCST90199831
Name: 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Hmdb Id: HMDB0008993
Super Pathway: NA
Sub Pathway: NA
Inchikey: JQKOHRZNEOQNJE

Denominator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Metabolite Accession: GCST90199844
Name: 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Hmdb Id: HMDB0005322
Super Pathway: NA
Sub Pathway: NA
Inchikey: HBZNVZIRJWODIB

Associated Genomic Regions

Region: rs9848779

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
3
Beta (Ratio):
-0.121
Position:
142652069
SE (Ratio):
0.012
Effect Allele:
C
Z-score (Ratio):
-10.273
Reference Allele:
G
-log10(P):
-55.334
MAF:
0.470
Beta (Num):
-0.107
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.013
SE (Den):
0.015
No CNV overlap
rQTL cluster:
132
Reaction Distance:
NA
Closest Genes:
PAQR9 U2SURP PCOLCE2 TRPC1 CHST2

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid metabolism.7[1], 8[2]

Ratio Explanation:

The ratio reflects the balance of specific glycerophosphoethanolamines, influenced by FADS desaturase activity which is crucial for polyunsaturated fatty acid biosynthesis.1[1], 2[2], 3[3], 4[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter desaturase activity, impacting the conversion of dietary fatty acids and influencing lipid profiles. This altered lipid metabolism is associated with an increased risk for cholelithiasis and type 2 diabetes, where dyslipidemia is a known factor.9[1], 10[2], 11[3], 12[4], 13[5], 14[6], 15[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data