1-stearoyl-2-oleoyl-gpe (18:0/18:1) to 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)

Numerator Metabolite

Structure of 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Metabolite Accession: GCST90199831
Name: 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Hmdb Id: HMDB0008993
Super Pathway: NA
Sub Pathway: NA
Inchikey: JQKOHRZNEOQNJE

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Metabolite Accession: GCST90200045
Name: 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Hmdb Id: HMDB0009003
Super Pathway: NA
Sub Pathway: NA
Inchikey: ANRKEHNWXKCXDB

Associated Genomic Regions

Region: rs174564

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.321
Position:
61588305
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
23.283
Reference Allele:
A
-log10(P):
-274.427
MAF:
0.344
Beta (Num):
0.098
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.222
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs200698395;rs6440123

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Clumped rQTL variant

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SNP Summary

Chr:
3
Beta (Ratio):
0.142
Position:
142659361
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
10.359
Reference Allele:
A
-log10(P):
-56.231
MAF:
0.354
Beta (Num):
0.112
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.030
SE (Den):
0.016
No CNV overlap
rQTL cluster:
132
Reaction Distance:
NA
Closest Genes:
PAQR9 U2SURP PCOLCE2 TRPC1 CHST2

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylethanolamine biosynthesis

Denominator Metabolite Explanation:

Phosphatidylethanolamine biosynthesis

Ratio Explanation:

The ratio reflects the conversion of the oleoyl (18:1) moiety to the arachidonoyl (20:4) moiety in phosphatidylethanolamines, a key step in polyunsaturated fatty acid metabolism.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS activity, influenced by genetic variants, decreases the conversion of oleic acid to arachidonic acid, altering the phosphatidylethanolamine pool. This shift in lipid composition is associated with disorders of lipoprotein metabolism and hypercholesterolemia.4[1], 5[2], 6[3], 7[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data