1-stearoyl-2-oleoyl-gpe (18:0/18:1) to 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*

Numerator Metabolite

Structure of 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Metabolite Accession: GCST90199831
Name: 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Hmdb Id: HMDB0008993
Super Pathway: NA
Sub Pathway: NA
Inchikey: JQKOHRZNEOQNJE

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Metabolite Accession: GCST90200054
Name: 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Hmdb Id: HMDB0005323
Super Pathway: NA
Sub Pathway: NA
Inchikey: DRIVXEVMDWCWLI

Associated Genomic Regions

Region: rs102275

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.234
Position:
61557803
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
16.115
Reference Allele:
T
-log10(P):
-132.854
MAF:
0.346
Beta (Num):
0.095
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.140
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

Region: rs200698395;rs6440123

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Clumped rQTL variant

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SNP Summary

Chr:
3
Beta (Ratio):
0.131
Position:
142659361
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
9.097
Reference Allele:
A
-log10(P):
-43.825
MAF:
0.354
Beta (Num):
0.112
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.020
SE (Den):
0.016
No CNV overlap
rQTL cluster:
132
Reaction Distance:
NA
Closest Genes:
PAQR9 U2SURP PCOLCE2 TRPC1 CHST2

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.3[1]

Denominator Metabolite Explanation:

Phosphatidylethanolamine biosynthesis.4[1]

Ratio Explanation:

The ratio reflects the balance between glycerophosphoethanolamines containing monounsaturated versus polyunsaturated fatty acids, influenced by FADS desaturase activity which converts oleic to arachidonic acid precursors.1[1], 2[2], 5[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 affect the conversion of fatty acids, influencing blood lipid levels.6[1], 7[2] Minor alleles are associated with lower total cholesterol and LDL but higher triglycerides, linking these genes to hypercholesterolemia risk.6[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data