1-stearoyl-2-oleoyl-gpe (18:0/18:1) to 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*

Numerator Metabolite

Structure of 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Metabolite Accession: GCST90199831
Name: 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Hmdb Id: HMDB0008993
Super Pathway: NA
Sub Pathway: NA
Inchikey: JQKOHRZNEOQNJE

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Metabolite Accession: GCST90200062
Name: 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Hmdb Id: HMDB0009789
Super Pathway: NA
Sub Pathway: NA
Inchikey: KIQYUSYSJTUGFZ

Associated Genomic Regions

Region: rs174564

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.248
Position:
61588305
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
13.309
Reference Allele:
A
-log10(P):
-91.390
MAF:
0.344
Beta (Num):
0.098
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.149
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs4683709

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Clumped rQTL variant

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SNP Summary

Chr:
3
Beta (Ratio):
0.181
Position:
142653249
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
9.790
Reference Allele:
G
-log10(P):
-50.438
MAF:
0.337
Beta (Num):
0.104
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.077
SE (Den):
0.016
No CNV overlap
rQTL cluster:
132
Reaction Distance:
NA
Closest Genes:
PAQR9 U2SURP PCOLCE2 TRPC1 CHST2

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, arachidonic acid metabolism.

Ratio Explanation:

This ratio reflects fatty acid desaturase activity; a higher ratio may indicate lower FADS1/FADS2 function, leading to reduced synthesis of arachidonic acid (20:4).7[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by the ratio, alters long-chain fatty acid profiles. This dysregulation of lipid metabolism is linked to hypercholesterolemia and an increased risk for cholelithiasis.8[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data