5alpha-androstan-3beta,17beta-diol disulfate to tauro-beta-muricholate

Numerator Metabolite

Metabolite Accession: GCST90199835
Name: 5alpha-androstan-3beta,17beta-diol disulfate
Hmdb Id: HMDB00493
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of tauro-beta-muricholate
Metabolite Accession: GCST90199719
Name: tauro-beta-muricholate
Hmdb Id: HMDB0000932
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSOLDPYUICCHJX

Associated Genomic Regions

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
7
Beta (Ratio):
-1.604
Position:
99075038
SE (Ratio):
0.062
Effect Allele:
C
Z-score (Ratio):
-25.692
Reference Allele:
T
-log10(P):
-333.515
MAF:
0.033
Beta (Num):
-0.672
Novel Locus:
No
SE (Num):
0.036
Beta (Den):
0.932
SE (Den):
0.046
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

Region: rs34048349

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
7
Beta (Ratio):
-0.890
Position:
100197642
SE (Ratio):
0.098
Effect Allele:
A
Z-score (Ratio):
-9.129
Reference Allele:
G
-log10(P):
-44.120
MAF:
0.015
Beta (Num):
-0.375
Novel Locus:
No
SE (Num):
0.053
Beta (Den):
0.515
SE (Den):
0.074
No CNV overlap
rQTL cluster:
89
Reaction Distance:
NA
Closest Genes:
FBXO24 PCOLCE MOSPD3 LRCH4 TFR2

LLM Analysis

Numerator Metabolite Explanation:

Androgen steroid biosynthesis.6[1], 7[2]

Denominator Metabolite Explanation:

Primary bile acid biosynthesis.8[1], 9[2], 10[3]

Ratio Explanation:

This ratio may reflect a balance between androgen hormone breakdown and bile acid synthesis, pathways potentially linked through shared lipid transport mechanisms.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered MOSPD3 function could disrupt the balance between steroid and bile acid metabolism, as both are linked to lipid transport and signaling. This disruption may influence systemic inflammatory (CRP, WBC) and metabolic (UA, BMI) phenotypes observed in BioBank Japan data.

Phenotype Driver:

Gene-centric:MOSPD3

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data