5alpha-androstan-3beta,17beta-diol disulfate to andro steroid monosulfate c19h28o6s (1)*

Numerator Metabolite

Metabolite Accession: GCST90199835
Name: 5alpha-androstan-3beta,17beta-diol disulfate
Hmdb Id: HMDB00493
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of andro steroid monosulfate c19h28o6s (1)*
Metabolite Accession: GCST90199860
Name: andro steroid monosulfate c19h28o6s (1)*
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-1.500
Position:
99075038
SE (Ratio):
0.051
Effect Allele:
C
Z-score (Ratio):
-29.166
Reference Allele:
T
-log10(P):
-428.931
MAF:
0.033
Beta (Num):
-0.672
Novel Locus:
No
SE (Num):
0.036
Beta (Den):
0.829
SE (Den):
0.041
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

Region: rs34048349

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-0.775
Position:
100197642
SE (Ratio):
0.077
Effect Allele:
A
Z-score (Ratio):
-10.025
Reference Allele:
G
-log10(P):
-52.787
MAF:
0.015
Beta (Num):
-0.375
Novel Locus:
No
SE (Num):
0.053
Beta (Den):
0.399
SE (Den):
0.063
No CNV overlap
rQTL cluster:
89
Reaction Distance:
NA
Closest Genes:
FBXO24 PCOLCE MOSPD3 LRCH4 TFR2

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism

Denominator Metabolite Explanation:

Androgen and estrogen metabolism

Ratio Explanation:

This ratio reflects the balance between a disulfated and a monosulfated androgen steroid, indicating activity in steroid sulfation pathways which can influence hormone bioavailability.5[1], 6[2], 7[3], 8[4], 9[5], 10[6]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants near ATP5J2, involved in cellular energy, are associated with the ratio of two sulfated androgens and phenotypes like BMI and height. Altered energy metabolism may influence steroid hormone balance, which in turn can affect growth and body composition.

Phenotype Driver:

Gene-centric:ATP5J2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data