pregnenediol disulfate (c21h34o8s2)* to 16a-hydroxy dhea 3-sulfate

Numerator Metabolite

Metabolite Accession: GCST90199840
Name: pregnenediol disulfate (c21h34o8s2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 16a-hydroxy dhea 3-sulfate
Metabolite Accession: GCST90199863
Name: 16a-hydroxy dhea 3-sulfate
Hmdb Id: HMDB0062544
Super Pathway: NA
Sub Pathway: NA
Inchikey: ALBNSVAJDFJRKQ

Associated Genomic Regions

Region: rs72818671

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.249
Position:
96775001
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
-11.191
Reference Allele:
G
-log10(P):
-65.263
MAF:
0.117
Beta (Num):
-0.088
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.162
SE (Den):
0.023
No CNV overlap
rQTL cluster:
70
Reaction Distance:
NA
Closest Genes:
CYP2C8 CYP2C9 CYP2C19 C10orf129 PDLIM1

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis, Progesterone Metabolism. 6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Androgen and Estrogen Metabolism. 9[1], 10[2], 11[3]

Ratio Explanation:

This ratio reflects the relative activity between progesterone metabolism pathways and DHEA hydroxylation, potentially influenced by CYP3A4 and other steroidogenic enzymes. 4[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in CYP enzymes like CYP3A4 alters steroid metabolism, affecting the balance of hormones that regulate skeletal growth and inflammation. 12[1], 13[2]This altered steroid profile, reflected in the ratio, is linked to variations in height and systemic inflammatory markers like C-reactive protein. 14[3], 15[4], 16[5]

Phenotype Driver:

Gene-centric:CYP3A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data