pregnenediol disulfate (c21h34o8s2)* to pregnenolone sulfate

Numerator Metabolite

Metabolite Accession: GCST90199840
Name: pregnenediol disulfate (c21h34o8s2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of pregnenolone sulfate
Metabolite Accession: GCST90199873
Name: pregnenolone sulfate
Hmdb Id: HMDB0000774
Super Pathway: NA
Sub Pathway: NA
Inchikey: DIJBBUIOWGGQOP

Associated Genomic Regions

Region: rs7475281

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.149
Position:
5252902
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
-8.536
Reference Allele:
A
-log10(P):
-38.817
MAF:
0.150
Beta (Num):
-0.056
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.093
SE (Den):
0.021
No CNV overlap
rQTL cluster:
76
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 TUBAL3

Region: rs4881413

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.148
Position:
5258450
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
-8.454
Reference Allele:
G
-log10(P):
-38.112
MAF:
0.150
Beta (Num):
-0.055
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.093
SE (Den):
0.021
No CNV overlap
rQTL cluster:
217
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 TUBAL3

Region: rs2151901

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.149
Position:
5262965
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
-8.501
Reference Allele:
A
-log10(P):
-38.515
MAF:
0.150
Beta (Num):
-0.055
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.094
SE (Den):
0.021
No CNV overlap
rQTL cluster:
285
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 TUBAL3

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis

Denominator Metabolite Explanation:

Steroidogenesis

Ratio Explanation:

This ratio may reflect AKR1C4 activity, where higher values suggest increased conversion of pregnenolone sulfate to downstream metabolites like pregnenediol disulfate.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

AKR1C4's role in steroid metabolism influences circulating steroid levels, which are associated with body weight and various liver function markers, including AST, ALT, and GGT, potentially through its impact on bile acid synthesis and lipid metabolism.4[1], 5[2]

Phenotype Driver:

Gene-centric:AKR1C4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data