Infomap Cluster 76

Metabolite Network

mQTL individually significant in locus
Novel rQTL
Known rQTL

Aggregated Cluster Evidence

Significant GTEx eQTL Colocalization (P-alpha < 5e-5)

Tissue Gene P(alpha) Associated Metabolites
Heart Left Ventricle NFATC3 1.10e-05 5alpha-androstan-3beta,17alpha-diol disulfate5alpha-pregnan-3beta,20alpha-diol disulfate
Whole Blood SLC7A6 1.54e-05 5alpha-androstan-3beta,17alpha-diol disulfate5alpha-pregnan-3beta,20alpha-diol disulfate
Thyroid PLA2G15 3.73e-05 5alpha-androstan-3beta,17alpha-diol disulfate5alpha-pregnan-3beta,20alpha-diol disulfate

Genomic Context

Displaying 17 SNPs on Chr 10 for Cluster 76.

Novel rQTL (▲)
Known rQTL (▲)

Cluster Summary

41

Metabolite Ratios (rQTLs)

26

Total Unique Metabolites

3

Unnamed Metabolites

Ratios in Cluster 76

Ratio Name Novel in Cluster Driven By
21-hydroxypregnenolone disulfate to androstenediol (3beta,17beta) disulfate (2) No
5alpha-androstan-3alpha,17alpha-diol monosulfate to 5alpha-androstan-3beta,17beta-diol monosulfate (2) No
5alpha-androstan-3alpha,17alpha-diol monosulfate to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No Numerator
5alpha-androstan-3alpha,17alpha-diol monosulfate to epiandrosterone sulfate No
5alpha-androstan-3alpha,17alpha-diol monosulfate to x-12112 No
5alpha-androstan-3beta,17alpha-diol disulfate to 5alpha-androstan-3beta,17beta-diol monosulfate (2) Yes
5alpha-androstan-3beta,17alpha-diol disulfate to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) Yes
5alpha-androstan-3beta,17alpha-diol disulfate to epiandrosterone sulfate Yes
5alpha-androstan-3beta,17beta-diol disulfate to 5alpha-androstan-3alpha,17alpha-diol monosulfate No
5alpha-androstan-3beta,17beta-diol disulfate to 5alpha-androstan-3beta,17alpha-diol disulfate Yes
5alpha-androstan-3beta,17beta-diol disulfate to 5alpha-pregnan-3beta,20beta-diol monosulfate (1) Yes
5alpha-androstan-3beta,17beta-diol disulfate to androstenediol (3alpha, 17alpha) monosulfate (3) Yes
5alpha-androstan-3beta,17beta-diol disulfate to androstenediol (3beta,17beta) disulfate (2) No
5alpha-androstan-3beta,17beta-diol disulfate to pregnenediol disulfate (c21h34o8s2)* Yes
5alpha-androstan-3beta,17beta-diol disulfate to x-24947 Yes
5alpha-androstan-3beta,17beta-diol monosulfate (2) to 5alpha-androstan-3alpha,17beta-diol monosulfate (1) Yes
5alpha-androstan-3beta,17beta-diol monosulfate (2) to x-24947 Yes
5alpha-pregnan-3beta,20alpha-diol disulfate to 5alpha-androstan-3alpha,17alpha-diol monosulfate No
5alpha-pregnan-3beta,20alpha-diol disulfate to 5alpha-androstan-3beta,17alpha-diol disulfate Yes
5alpha-pregnan-3beta,20alpha-diol disulfate to 5alpha-pregnan-3beta,20beta-diol monosulfate (1) Yes
5alpha-pregnan-3beta,20alpha-diol disulfate to androstenediol (3beta,17beta) disulfate (2) No
5alpha-pregnan-3beta,20alpha-diol disulfate to pregnanediol-3-glucuronide Yes
5alpha-pregnan-3beta,20alpha-diol disulfate to pregnenediol disulfate (c21h34o8s2)* Yes
5alpha-pregnan-3beta,20alpha-diol disulfate to pregnenediol sulfate (c21h34o5s)* Yes
5alpha-pregnan-3beta,20alpha-diol disulfate to x-21441 Yes
5alpha-pregnan-3beta,20alpha-diol disulfate to x-24947 Yes
5alpha-pregnan-3beta,20alpha-diol monosulfate (2) to pregnenediol sulfate (c21h34o5s)* Yes
5alpha-pregnan-3beta,20beta-diol monosulfate (1) to 5alpha-androstan-3beta,17beta-diol monosulfate (2) Yes
5alpha-pregnan-3beta,20beta-diol monosulfate (1) to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) Yes
5alpha-pregnan-3beta,20beta-diol monosulfate (1) to epiandrosterone sulfate Yes
andro steroid monosulfate c19h28o6s (1)* to 16a-hydroxy dhea 3-sulfate Yes
androstenediol (3alpha, 17alpha) monosulfate (3) to epiandrosterone sulfate Yes
androstenediol (3beta,17beta) disulfate (2) to 5alpha-androstan-3beta,17beta-diol monosulfate (2) No
androstenediol (3beta,17beta) disulfate (2) to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
androstenediol (3beta,17beta) disulfate (2) to andro steroid monosulfate c19h28o6s (1)* No
androstenediol (3beta,17beta) disulfate (2) to epiandrosterone sulfate No
androstenediol (3beta,17beta) disulfate (2) to x-12112 No
epiandrosterone sulfate to androsterone sulfate Yes
epiandrosterone sulfate to x-24947 Yes
n6,n6-dimethyllysine to x-12112 No
n6-methyllysine to x-12112 No
pregnanediol-3-glucuronide to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) Yes
pregnenediol disulfate (c21h34o8s2)* to pregnenolone sulfate Yes
pregnenetriol disulfate* to 5alpha-androstan-3beta,17beta-diol disulfate Yes
pregnenetriol disulfate* to 5alpha-pregnan-3beta,20alpha-diol disulfate Yes
pregnenetriol sulfate* to pregnenolone sulfate Yes
pregnenolone sulfate to 5alpha-androstan-3alpha,17alpha-diol monosulfate No
pregnenolone sulfate to 5alpha-pregnan-3beta,20beta-diol monosulfate (1) Yes
pregnenolone sulfate to androstenediol (3beta,17beta) disulfate (2) No
pregnenolone sulfate to pregnenediol sulfate (c21h34o5s)* Yes