androstenediol (3beta,17beta) disulfate (2) to epiandrosterone sulfate

Numerator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (2)
Metabolite Accession: GCST90199851
Name: androstenediol (3beta,17beta) disulfate (2)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Denominator Metabolite

Structure of epiandrosterone sulfate
Metabolite Accession: GCST90199752
Name: epiandrosterone sulfate
Hmdb Id: HMDB0062657
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs74827952

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.217
Position:
5245196
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
-10.307
Reference Allele:
G
-log10(P):
-55.688
MAF:
0.148
Beta (Num):
-0.131
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.086
SE (Den):
0.020
No CNV overlap
rQTL cluster:
76
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 AKR1C2

Region: rs4881413

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.214
Position:
5258450
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
-10.175
Reference Allele:
G
-log10(P):
-54.319
MAF:
0.150
Beta (Num):
-0.127
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.087
SE (Den):
0.020
No CNV overlap
rQTL cluster:
217
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 TUBAL3

Region: rs2151901

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.214
Position:
5262965
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
-10.185
Reference Allele:
A
-log10(P):
-54.425
MAF:
0.150
Beta (Num):
-0.126
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.088
SE (Den):
0.020
No CNV overlap
rQTL cluster:
285
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 TUBAL3

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis, Androgen and Estrogen Metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Androgen and Estrogen Metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio of androstenediol (3beta,17beta) disulfate to epiandrosterone sulfate reflects activity in androgen metabolism, where AKR1C4 is involved in steroid interconversion and catabolism.1[1], 10[2], 11[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

AKR1C4 is a major hepatic enzyme that metabolizes steroids and is associated with liver health.12[1], 13[2], 14[3] Altered AKR1C4 activity can impact steroid and bile acid levels, influencing liver function markers like ALT, AST, and GGT, and inflammatory markers such as CRP and uric acid.12[4], 13[5]

Phenotype Driver:

Gene-centric:AKR1C4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data