androstenediol (3beta,17beta) disulfate (2) to andro steroid monosulfate c19h28o6s (1)*

Numerator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (2)
Metabolite Accession: GCST90199851
Name: androstenediol (3beta,17beta) disulfate (2)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Denominator Metabolite

Structure of andro steroid monosulfate c19h28o6s (1)*
Metabolite Accession: GCST90199860
Name: andro steroid monosulfate c19h28o6s (1)*
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs4881413

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.215
Position:
5258450
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
-10.168
Reference Allele:
G
-log10(P):
-54.247
MAF:
0.150
Beta (Num):
-0.127
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.089
SE (Den):
0.022
No CNV overlap
rQTL cluster:
217
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 TUBAL3

Region: rs2151901

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.215
Position:
5262965
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
-10.139
Reference Allele:
A
-log10(P):
-53.952
MAF:
0.150
Beta (Num):
-0.126
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.089
SE (Den):
0.022
No CNV overlap
rQTL cluster:
285
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 TUBAL3

Region: rs151227875

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.215
Position:
5297321
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
-10.355
Reference Allele:
C
-log10(P):
-56.183
MAF:
0.156
Beta (Num):
-0.127
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.088
SE (Den):
0.022
No CNV overlap
rQTL cluster:
76
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 UCN3 TUBAL3 AKR1C3

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism. 5[1], 6[2]

Denominator Metabolite Explanation:

Androgen and estrogen metabolism. 5[1], 6[2]

Ratio Explanation:

The ratio likely reflects AKR1C4 activity in steroid hormone clearance; altered AKR1C4 function affects the balance between different sulfated androstenediol species. 2[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered AKR1C4 activity dysregulates steroid and bile acid metabolism in the liver, linking to phenotypes like elevated GGT, triglycerides, and bilirubin, which are markers for liver dysfunction and metabolic health issues seen in the associated phenotypes. 7[1], 8[2]

Phenotype Driver:

Gene-centric:AKR1C4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data