5alpha-androstan-3alpha,17alpha-diol monosulfate to 5alpha-androstan-3beta,17beta-diol monosulfate (2)

Numerator Metabolite

Structure of 5alpha-androstan-3alpha,17alpha-diol monosulfate
Metabolite Accession: GCST90199850
Name: 5alpha-androstan-3alpha,17alpha-diol monosulfate
Hmdb Id: HMDB0000412
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBMYJHIOYJEBSB

Denominator Metabolite

Metabolite Accession: GCST90199855
Name: 5alpha-androstan-3beta,17beta-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs77697233

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.329
Position:
5246125
SE (Ratio):
0.026
Effect Allele:
T
Z-score (Ratio):
-12.518
Reference Allele:
C
-log10(P):
-81.106
MAF:
0.132
Beta (Num):
-0.229
Novel Locus:
No
SE (Num):
0.026
Beta (Den):
0.100
SE (Den):
0.022
No CNV overlap
rQTL cluster:
76
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 AKR1C2

Region: rs4881413

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.324
Position:
5258450
SE (Ratio):
0.026
Effect Allele:
T
Z-score (Ratio):
-12.352
Reference Allele:
G
-log10(P):
-79.033
MAF:
0.133
Beta (Num):
-0.226
Novel Locus:
No
SE (Num):
0.026
Beta (Den):
0.097
SE (Den):
0.022
No CNV overlap
rQTL cluster:
217
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 TUBAL3

Region: rs2151901

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.326
Position:
5262965
SE (Ratio):
0.026
Effect Allele:
C
Z-score (Ratio):
-12.427
Reference Allele:
A
-log10(P):
-79.971
MAF:
0.133
Beta (Num):
-0.228
Novel Locus:
No
SE (Num):
0.026
Beta (Den):
0.098
SE (Den):
0.022
No CNV overlap
rQTL cluster:
285
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 TUBAL3

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Androgen and estrogen metabolism.5[1], 4[2]

Ratio Explanation:

The ratio reflects the stereospecific reduction activity of AKR1C4, converting 5-alpha-dihydrotestosterone metabolites into less active forms, influencing androgenic and estrogenic balance.6[1], 4[2]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

AKR1C4's role in steroid and bile acid metabolism likely influences the listed liver-related (ALP, GGT, Total Bilirubin) and metabolic (Total Cholesterol, Triglycerides, Height, Weight, Hematocrit, Hemoglobin) phenotypes.1[1], 7[2], 8[3]

Phenotype Driver:

Gene-centric:AKR1C4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data