pregnenetriol sulfate* to pregnenolone sulfate

Numerator Metabolite

Structure of pregnenetriol sulfate*
Metabolite Accession: GCST90200241
Name: pregnenetriol sulfate*
Hmdb Id: HMDB0241920
Super Pathway: NA
Sub Pathway: NA
Inchikey: DENIQPHQUIGDJZ

Denominator Metabolite

Structure of pregnenolone sulfate
Metabolite Accession: GCST90199873
Name: pregnenolone sulfate
Hmdb Id: HMDB0000774
Super Pathway: NA
Sub Pathway: NA
Inchikey: DIJBBUIOWGGQOP

Associated Genomic Regions

Region: rs17134601

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.128
Position:
5261175
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
-7.538
Reference Allele:
A
-log10(P):
-30.675
MAF:
0.150
Beta (Num):
-0.035
Novel Locus:
Yes ✔️
SE (Num):
0.018
Beta (Den):
0.093
SE (Den):
0.021
No CNV overlap
rQTL cluster:
76
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 TUBAL3

Region: rs2151901

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.128
Position:
5262965
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
-7.490
Reference Allele:
A
-log10(P):
-30.310
MAF:
0.150
Beta (Num):
-0.034
Novel Locus:
Yes ✔️
SE (Num):
0.018
Beta (Den):
0.094
SE (Den):
0.021
No CNV overlap
rQTL cluster:
285
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 TUBAL3

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis

Denominator Metabolite Explanation:

Steroidogenesis

Ratio Explanation:

The ratio reflects the balance of steroid hormone production and metabolism; however, the direct enzymatic relationship between AKR1C4 and these specific sulfates is not clearly established.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

AKR1C4's role in steroid and bile acid metabolism links it to liver function (GGT, ALP, TBil) and lipid metabolism (TC, TG), influencing body weight.5[1], 6[2]

Phenotype Driver:

Gene-centric:AKR1C4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data