pregnenetriol disulfate* to 5alpha-androstan-3beta,17beta-diol disulfate

Numerator Metabolite

Metabolite Accession: GCST90200238
Name: pregnenetriol disulfate*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90199835
Name: 5alpha-androstan-3beta,17beta-diol disulfate
Hmdb Id: HMDB00493
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs77697233

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.146
Position:
5246125
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
-7.620
Reference Allele:
C
-log10(P):
-31.307
MAF:
0.149
Beta (Num):
-0.058
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.088
SE (Den):
0.019
No CNV overlap
rQTL cluster:
76
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 AKR1C2

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis

Denominator Metabolite Explanation:

Androgen and estrogen metabolism

Ratio Explanation:

The ratio reflects AKR1C4 activity, where higher values suggest reduced conversion of pregnenetriol precursors to downstream androgens like 5alpha-androstan-3beta,17beta-diol.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered AKR1C4 activity, reflected in the steroid ratio, may influence the balance of androgens and other steroid hormones, potentially affecting phenotypes like BMI, cholesterol levels, and hematological traits through its role in overall steroid homeostasis.2[1]

Phenotype Driver:

Gene-centric:AKR1C4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data