andro steroid monosulfate c19h28o6s (1)* to 16a-hydroxy dhea 3-sulfate

Numerator Metabolite

Structure of andro steroid monosulfate c19h28o6s (1)*
Metabolite Accession: GCST90199860
Name: andro steroid monosulfate c19h28o6s (1)*
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Denominator Metabolite

Structure of 16a-hydroxy dhea 3-sulfate
Metabolite Accession: GCST90199863
Name: 16a-hydroxy dhea 3-sulfate
Hmdb Id: HMDB0062544
Super Pathway: NA
Sub Pathway: NA
Inchikey: ALBNSVAJDFJRKQ

Associated Genomic Regions

Region: rs3750572

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.128
Position:
5247376
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
8.443
Reference Allele:
T
-log10(P):
-38.014
MAF:
0.150
Beta (Num):
0.088
Novel Locus:
Yes ✔️
SE (Num):
0.022
Beta (Den):
-0.039
SE (Den):
0.021
No CNV overlap
rQTL cluster:
76
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 AKR1C2

Region: rs4881413

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.126
Position:
5258450
SE (Ratio):
0.015
Effect Allele:
T
Z-score (Ratio):
8.326
Reference Allele:
G
-log10(P):
-37.018
MAF:
0.151
Beta (Num):
0.089
Novel Locus:
Yes ✔️
SE (Num):
0.022
Beta (Den):
-0.037
SE (Den):
0.021
No CNV overlap
rQTL cluster:
217
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 TUBAL3

Region: rs2151901

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.126
Position:
5262965
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
8.323
Reference Allele:
A
-log10(P):
-36.998
MAF:
0.151
Beta (Num):
0.089
Novel Locus:
Yes ✔️
SE (Num):
0.022
Beta (Den):
-0.037
SE (Den):
0.021
No CNV overlap
rQTL cluster:
285
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 TUBAL3

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism.3[1]

Denominator Metabolite Explanation:

Androgen and estrogen metabolism.4[1]

Ratio Explanation:

The ratio likely reflects AKR1C4 activity, which metabolizes various steroids, influencing the balance between different androgenic compounds.5[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered AKR1C4 function, reflected by the steroid ratio, impacts liver-centric processes like bile acid synthesis and lipid metabolism, leading to changes in associated clinical markers like ALP, GGT, cholesterol, and triglycerides.7[1], 8[2], 9[3]

Phenotype Driver:

Gene-centric:AKR1C4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data