androstenediol (3beta,17beta) disulfate (2) to 5alpha-androstan-3beta,17beta-diol monosulfate (2)

Numerator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (2)
Metabolite Accession: GCST90199851
Name: androstenediol (3beta,17beta) disulfate (2)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Denominator Metabolite

Metabolite Accession: GCST90199855
Name: 5alpha-androstan-3beta,17beta-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs77697233

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
10
Beta (Ratio):
-0.228
Position:
5246125
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
-9.849
Reference Allele:
C
-log10(P):
-51.023
MAF:
0.149
Beta (Num):
-0.129
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.100
SE (Den):
0.022
No CNV overlap
rQTL cluster:
76
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 AKR1C2

Region: rs4881413

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
10
Beta (Ratio):
-0.224
Position:
5258450
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
-9.674
Reference Allele:
G
-log10(P):
-49.296
MAF:
0.150
Beta (Num):
-0.127
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.097
SE (Den):
0.022
No CNV overlap
rQTL cluster:
217
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 TUBAL3

Region: rs2151901

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
10
Beta (Ratio):
-0.224
Position:
5262965
SE (Ratio):
0.023
Effect Allele:
C
Z-score (Ratio):
-9.654
Reference Allele:
A
-log10(P):
-49.103
MAF:
0.150
Beta (Num):
-0.126
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.098
SE (Den):
0.022
No CNV overlap
rQTL cluster:
285
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 TUBAL3

LLM Analysis

Numerator Metabolite Explanation:

Androgen metabolism, steroid sulfation.6[1], 7[2]

Denominator Metabolite Explanation:

Androgen metabolism, steroid sulfation.6[1], 8[2]

Ratio Explanation:

The ratio reflects the balance in androgen catabolism, particularly the conversion of androgens to their less active forms, a process influenced by AKR1C4.9[1], 10[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in AKR1C4 alter its efficiency in hepatic steroid and bile acid metabolism, reflected by the ratio and causally linked to liver-related phenotypes like GGT, ALP, and bilirubin levels.11[1], 5[2], 12[3]

Phenotype Driver:

Gene-centric:[AKR1C4]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data