5alpha-androstan-3alpha,17alpha-diol monosulfate to epiandrosterone sulfate

Numerator Metabolite

Structure of 5alpha-androstan-3alpha,17alpha-diol monosulfate
Metabolite Accession: GCST90199850
Name: 5alpha-androstan-3alpha,17alpha-diol monosulfate
Hmdb Id: HMDB0000412
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBMYJHIOYJEBSB

Denominator Metabolite

Structure of epiandrosterone sulfate
Metabolite Accession: GCST90199752
Name: epiandrosterone sulfate
Hmdb Id: HMDB0062657
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs77697233

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
10
Beta (Ratio):
-0.317
Position:
5246125
SE (Ratio):
0.026
Effect Allele:
T
Z-score (Ratio):
-11.969
Reference Allele:
C
-log10(P):
-74.343
MAF:
0.132
Beta (Num):
-0.229
Novel Locus:
No
SE (Num):
0.026
Beta (Den):
0.088
SE (Den):
0.020
No CNV overlap
rQTL cluster:
76
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 AKR1C2

Region: rs4881413

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
10
Beta (Ratio):
-0.313
Position:
5258450
SE (Ratio):
0.026
Effect Allele:
T
Z-score (Ratio):
-11.865
Reference Allele:
G
-log10(P):
-73.091
MAF:
0.133
Beta (Num):
-0.226
Novel Locus:
No
SE (Num):
0.026
Beta (Den):
0.087
SE (Den):
0.020
No CNV overlap
rQTL cluster:
217
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 TUBAL3

Region: rs2151901

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
10
Beta (Ratio):
-0.316
Position:
5262965
SE (Ratio):
0.026
Effect Allele:
C
Z-score (Ratio):
-11.965
Reference Allele:
A
-log10(P):
-74.297
MAF:
0.133
Beta (Num):
-0.228
Novel Locus:
No
SE (Num):
0.026
Beta (Den):
0.088
SE (Den):
0.020
No CNV overlap
rQTL cluster:
285
Reaction Distance:
NA
Closest Genes:
AKR1C4 AKR1CL1 AKR1C3 UCN3 TUBAL3

LLM Analysis

Numerator Metabolite Explanation:

Androgen metabolism. 4[1]

Denominator Metabolite Explanation:

Androgen metabolism. 5[1], 4[2], 6[3]

Ratio Explanation:

The ratio reflects the conversion of 5alpha-androstan-3alpha,17alpha-diol monosulfate to epiandrosterone sulfate, a process likely influenced by AKR1C4 activity in steroid metabolism.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced AKR1C4 activity may alter steroid profiles, impacting pathways governed by the Liver X Receptor which regulates lipid and carbohydrate metabolism, thus influencing phenotypes like cholesterol, triglycerides, and ALP levels. 1[1], 7[2], 2[3], 8[4], 9[5]

Phenotype Driver:

Gene-centric:AKR1C4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data