5alpha-androstan-3beta,17beta-diol monosulfate (2) to andro steroid monosulfate c19h28o6s (1)*

Numerator Metabolite

Metabolite Accession: GCST90199855
Name: 5alpha-androstan-3beta,17beta-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of andro steroid monosulfate c19h28o6s (1)*
Metabolite Accession: GCST90199860
Name: andro steroid monosulfate c19h28o6s (1)*
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-1.920
Position:
99075038
SE (Ratio):
0.060
Effect Allele:
C
Z-score (Ratio):
-31.740
Reference Allele:
T
-log10(P):
-507.403
MAF:
0.021
Beta (Num):
-1.091
Novel Locus:
No
SE (Num):
0.053
Beta (Den):
0.829
SE (Den):
0.041
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

Region: rs34048349

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-0.910
Position:
100197642
SE (Ratio):
0.084
Effect Allele:
A
Z-score (Ratio):
-10.770
Reference Allele:
G
-log10(P):
-60.606
MAF:
0.012
Beta (Num):
-0.511
Novel Locus:
No
SE (Num):
0.070
Beta (Den):
0.399
SE (Den):
0.063
No CNV overlap
rQTL cluster:
89
Reaction Distance:
NA
Closest Genes:
FBXO24 PCOLCE MOSPD3 LRCH4 TFR2

LLM Analysis

Numerator Metabolite Explanation:

Androgen and Steroid Metabolism

Denominator Metabolite Explanation:

Androgen and Pregnenolone Steroid Metabolism3[1]

Ratio Explanation:

The ratio likely reflects altered steroidogenesis, where the conversion or clearance of androsterone and related sulfates is modified, potentially impacting androgenic pathways.4[1], 5[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The gene PCOLCE is linked to collagen synthesis.1[1], 2[2] Altered steroid hormone levels, influenced by factors like BMI and inflammation, can affect PCOLCE expression and collagen turnover.6[3], 7[4], 8[5] This interplay between steroid metabolism and collagen regulation may contribute to the diverse observed phenotypes like changes in BMI and inflammatory markers such as C-reactive protein.9[6], 10[7]

Phenotype Driver:

Gene-centric:PCOLCE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data