5alpha-androstan-3beta,17beta-diol monosulfate (2) to glyco-beta-muricholate**

Numerator Metabolite

Metabolite Accession: GCST90199855
Name: 5alpha-androstan-3beta,17beta-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200179
Name: glyco-beta-muricholate**
Hmdb Id: HMDB0341323
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-1.980
Position:
99075038
SE (Ratio):
0.074
Effect Allele:
C
Z-score (Ratio):
-26.916
Reference Allele:
T
-log10(P):
-365.760
MAF:
0.021
Beta (Num):
-1.091
Novel Locus:
No
SE (Num):
0.053
Beta (Den):
0.889
SE (Den):
0.043
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

Region: rs34048349

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-0.954
Position:
100197642
SE (Ratio):
0.104
Effect Allele:
A
Z-score (Ratio):
-9.204
Reference Allele:
G
-log10(P):
-44.813
MAF:
0.012
Beta (Num):
-0.511
Novel Locus:
No
SE (Num):
0.070
Beta (Den):
0.443
SE (Den):
0.065
No CNV overlap
rQTL cluster:
89
Reaction Distance:
NA
Closest Genes:
FBXO24 PCOLCE MOSPD3 LRCH4 TFR2

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism, Steroidogenesis4[1]

Denominator Metabolite Explanation:

Primary bile acid biosynthesis, glycine conjugation5[1], 6[2]

Ratio Explanation:

none

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

PCOLCE enhances collagen synthesis and is linked to inflammation and tissue remodeling.1[1], 2[2], 7[3] This may influence phenotypes like BMI, height, and inflammatory markers (CRP, WBC count), while its connection to uric acid is less direct but potentially linked to kidney function.2[4], 8[5], 9[6], 10[7], 11[8], 12[9]

Phenotype Driver:

Gene-centric:PCOLCE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data