5alpha-androstan-3alpha,17beta-diol monosulfate (1) to andro steroid monosulfate c19h28o6s (1)*

Numerator Metabolite

Metabolite Accession: GCST90199858
Name: 5alpha-androstan-3alpha,17beta-diol monosulfate (1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of andro steroid monosulfate c19h28o6s (1)*
Metabolite Accession: GCST90199860
Name: andro steroid monosulfate c19h28o6s (1)*
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-2.169
Position:
99075038
SE (Ratio):
0.062
Effect Allele:
C
Z-score (Ratio):
-35.231
Reference Allele:
T
-log10(P):
-624.395
MAF:
0.023
Beta (Num):
-1.340
Novel Locus:
No
SE (Num):
0.049
Beta (Den):
0.829
SE (Den):
0.041
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

Region: rs34048349

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-1.001
Position:
100197642
SE (Ratio):
0.089
Effect Allele:
A
Z-score (Ratio):
-11.279
Reference Allele:
G
-log10(P):
-66.260
MAF:
0.013
Beta (Num):
-0.602
Novel Locus:
No
SE (Num):
0.068
Beta (Den):
0.399
SE (Den):
0.063
No CNV overlap
rQTL cluster:
89
Reaction Distance:
NA
Closest Genes:
FBXO24 PCOLCE MOSPD3 LRCH4 TFR2

LLM Analysis

Numerator Metabolite Explanation:

Androgen and Estrogen Metabolism.6[1], 7[2]

Denominator Metabolite Explanation:

Androgen and Estrogen Metabolism.6[1], 8[2]

Ratio Explanation:

The ratio likely reflects variance in steroid sulfation or clearance. PCOLCE is not a known steroid-metabolizing enzyme, suggesting an indirect link.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

PCOLCE's role in extracellular matrix organization may influence tissue structure and signaling, impacting systemic processes like inflammation (CRP, WBC), metabolism (BMI, Uric Acid), and growth (Height).4[1], 9[2], 10[3], 11[4], 12[5], 13[6], 14[7]

Phenotype Driver:

Gene-centric:PCOLCE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data