andro steroid monosulfate c19h28o6s (1)* to DHEAS

Numerator Metabolite

Structure of andro steroid monosulfate c19h28o6s (1)*
Metabolite Accession: GCST90199860
Name: andro steroid monosulfate c19h28o6s (1)*
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Denominator Metabolite

Structure of dehydroepiandrosterone sulfate (dhea-s)
Metabolite Accession: GCST90199673
Name: dehydroepiandrosterone sulfate (dhea-s)
Hmdb Id: HMDB0001032
Super Pathway: NA
Sub Pathway: NA
Inchikey: CZWCKYRVOZZJNM

Associated Genomic Regions

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
1.252
Position:
99075038
SE (Ratio):
0.044
Effect Allele:
C
Z-score (Ratio):
28.414
Reference Allele:
T
-log10(P):
-407.260
MAF:
0.036
Beta (Num):
0.829
Novel Locus:
No
SE (Num):
0.041
Beta (Den):
-0.423
SE (Den):
0.037
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

Region: rs34048349

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
0.646
Position:
100197642
SE (Ratio):
0.066
Effect Allele:
A
Z-score (Ratio):
9.774
Reference Allele:
G
-log10(P):
-50.279
MAF:
0.016
Beta (Num):
0.399
Novel Locus:
No
SE (Num):
0.063
Beta (Den):
-0.247
SE (Den):
0.054
No CNV overlap
rQTL cluster:
89
Reaction Distance:
NA
Closest Genes:
FBXO24 PCOLCE MOSPD3 LRCH4 TFR2

LLM Analysis

Numerator Metabolite Explanation:

Androgen and Estrogen Metabolism.7[1]

Denominator Metabolite Explanation:

Androgen and Estrogen Metabolism.8[1], 9[2]

Ratio Explanation:

This ratio may reflect the rate of DHEAS conversion to other downstream androgenic steroids, a process potentially influenced by CYP2C8 activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered CYP2C8 activity can modify steroid metabolism, impacting downstream signaling. This dysregulation is linked to obesity, which is a state of chronic low-grade inflammation characterized by elevated white blood cell counts and C-reactive protein.10[1], 11[2], 12[3]

Phenotype Driver:

Gene-centric:CYP2C8

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data