andro steroid monosulfate c19h28o6s (1)* to epiandrosterone sulfate

Numerator Metabolite

Structure of andro steroid monosulfate c19h28o6s (1)*
Metabolite Accession: GCST90199860
Name: andro steroid monosulfate c19h28o6s (1)*
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Denominator Metabolite

Structure of epiandrosterone sulfate
Metabolite Accession: GCST90199752
Name: epiandrosterone sulfate
Hmdb Id: HMDB0062657
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
2.151
Position:
99075038
SE (Ratio):
0.054
Effect Allele:
C
Z-score (Ratio):
39.874
Reference Allele:
T
-log10(P):
-798.875
MAF:
0.036
Beta (Num):
0.829
Novel Locus:
No
SE (Num):
0.041
Beta (Den):
-1.322
SE (Den):
0.038
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

Region: rs34048349

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
1.033
Position:
100197642
SE (Ratio):
0.083
Effect Allele:
A
Z-score (Ratio):
12.498
Reference Allele:
G
-log10(P):
-80.860
MAF:
0.016
Beta (Num):
0.399
Novel Locus:
No
SE (Num):
0.063
Beta (Den):
-0.634
SE (Den):
0.058
No CNV overlap
rQTL cluster:
89
Reaction Distance:
NA
Closest Genes:
FBXO24 PCOLCE MOSPD3 LRCH4 TFR2

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Androgen and estrogen metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio of these two sulfated androgen isomers, androsterone and epiandrosterone, likely reflects upstream steroidogenic enzyme activity converting precursors like DHEA-S.9[1], 10[2], 11[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in ZNF394, a transcription factor, may alter steroidogenesis, indicated by the isomer ratio. This altered androgen profile is associated with phenotypes like Body Mass Index, C-reactive protein, and uric acid levels, which are known to be influenced by androgens.1[1], 12[2], 13[3], 14[4], 15[5], 16[6]

Phenotype Driver:

Gene-centric:ZNF394

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data