16a-hydroxy dhea 3-sulfate to epiandrosterone sulfate

Numerator Metabolite

Structure of 16a-hydroxy dhea 3-sulfate
Metabolite Accession: GCST90199863
Name: 16a-hydroxy dhea 3-sulfate
Hmdb Id: HMDB0062544
Super Pathway: NA
Sub Pathway: NA
Inchikey: ALBNSVAJDFJRKQ

Denominator Metabolite

Structure of epiandrosterone sulfate
Metabolite Accession: GCST90199752
Name: epiandrosterone sulfate
Hmdb Id: HMDB0062657
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
2.367
Position:
99075038
SE (Ratio):
0.053
Effect Allele:
C
Z-score (Ratio):
44.613
Reference Allele:
T
-log10(P):
-999.166
MAF:
0.034
Beta (Num):
1.044
Novel Locus:
No
SE (Num):
0.039
Beta (Den):
-1.322
SE (Den):
0.038
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

Region: rs34048349

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
1.125
Position:
100197642
SE (Ratio):
0.082
Effect Allele:
A
Z-score (Ratio):
13.755
Reference Allele:
G
-log10(P):
-97.454
MAF:
0.015
Beta (Num):
0.491
Novel Locus:
No
SE (Num):
0.059
Beta (Den):
-0.634
SE (Den):
0.058
No CNV overlap
rQTL cluster:
89
Reaction Distance:
NA
Closest Genes:
FBXO24 PCOLCE MOSPD3 LRCH4 TFR2

LLM Analysis

Numerator Metabolite Explanation:

Androgen and Estrogen Metabolism.5[1], 6[2], 7[3], 8[4]

Denominator Metabolite Explanation:

Androgen and Estrogen Metabolism.5[1], 9[2], 10[3]

Ratio Explanation:

This ratio reflects the balance between two branches of DHEA metabolism; its association with PCOLCE suggests an indirect link via extracellular matrix biology.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

PCOLCE variants may alter extracellular matrix biology, influencing body composition (BMI, Height).2[1], 11[2], 12[3] This systemic change could secondarily affect steroid metabolism and inflammatory markers (CRP, WBC), which are associated with metabolic health and tissue remodeling.13[4], 14[5]

Phenotype Driver:

Gene-centric:PCOLCE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data