16a-hydroxy dhea 3-sulfate to androsterone sulfate

Numerator Metabolite

Structure of 16a-hydroxy dhea 3-sulfate
Metabolite Accession: GCST90199863
Name: 16a-hydroxy dhea 3-sulfate
Hmdb Id: HMDB0062544
Super Pathway: NA
Sub Pathway: NA
Inchikey: ALBNSVAJDFJRKQ

Denominator Metabolite

Structure of androsterone sulfate
Metabolite Accession: GCST90200674
Name: androsterone sulfate
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
2.548
Position:
99075038
SE (Ratio):
0.054
Effect Allele:
C
Z-score (Ratio):
46.780
Reference Allele:
T
-log10(P):
-1098.263
MAF:
0.034
Beta (Num):
1.044
Novel Locus:
No
SE (Num):
0.039
Beta (Den):
-1.504
SE (Den):
0.038
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

Region: rs34048349

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
1.227
Position:
100197642
SE (Ratio):
0.084
Effect Allele:
A
Z-score (Ratio):
14.548
Reference Allele:
G
-log10(P):
-108.735
MAF:
0.015
Beta (Num):
0.491
Novel Locus:
No
SE (Num):
0.059
Beta (Den):
-0.736
SE (Den):
0.060
No CNV overlap
rQTL cluster:
89
Reaction Distance:
NA
Closest Genes:
FBXO24 PCOLCE MOSPD3 LRCH4 TFR2

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism.5[1], 6[2], 7[3], 8[4]

Denominator Metabolite Explanation:

Androgen and estrogen metabolism.9[1], 10[2], 11[3], 12[4]

Ratio Explanation:

The ratio reflects the relative activity between 16-hydroxylation of DHEA and the formation of downstream androgen metabolites like androsterone, potentially influenced by iron-dependent enzymes.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic factors like TFR2, which is involved in iron homeostasis, may alter steroid metabolism as reflected by the ratio. This change could systemically influence metabolic and inflammatory phenotypes such as BMI, C-reactive protein, and white blood cell count, linking the gene to the observed traits.13[1], 14[2], 15[3], 16[4], 17[5]

Phenotype Driver:

Gene-centric:TFR2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data