oleoyl-linoleoyl-glycerol (18:1/18:2) [2] to sphingomyelin (d18:1/20:0, d16:1/22:0)*

Numerator Metabolite

Structure of oleoyl-linoleoyl-glycerol (18:1/18:2) [2]
Metabolite Accession: GCST90199914
Name: oleoyl-linoleoyl-glycerol (18:1/18:2) [2]
Hmdb Id: HMDB0007219
Super Pathway: NA
Sub Pathway: NA
Inchikey: BLZVZPYMHLXLHG

Denominator Metabolite

Structure of sphingomyelin (d18:1/20:0, d16:1/22:0)*
Metabolite Accession: GCST90200001
Name: sphingomyelin (d18:1/20:0, d16:1/22:0)*
Hmdb Id: HMDB0012102
Super Pathway: NA
Sub Pathway: NA
Inchikey: AADLTHQNYQJHQV

Associated Genomic Regions

Region: rs72654473

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
19
Beta (Ratio):
0.309
Position:
45414399
SE (Ratio):
0.033
Effect Allele:
A
Z-score (Ratio):
9.378
Reference Allele:
C
-log10(P):
-46.450
MAF:
0.107
Beta (Num):
0.144
Novel Locus:
No
SE (Num):
0.025
Beta (Den):
-0.166
SE (Den):
0.024
No CNV overlap
rQTL cluster:
8
Reaction Distance:
NA
Closest Genes:
APOE APOC1 TOMM40 PVRL2 APOC4

LLM Analysis

Numerator Metabolite Explanation:

Triglyceride and diacylglycerol metabolism.5[1]

Denominator Metabolite Explanation:

Sphingolipid metabolism and ceramide synthesis.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects the balance between glycerolipid and sphingolipid pools within lipoproteins, influenced by APOC1's modulation of lipoprotein metabolism.1[1], 4[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in APOC1 alter its function, leading to dysregulated metabolism of triglyceride-rich lipoproteins, which is reflected in the altered lipid ratio and increases the risk of atherosclerosis and related cardiovascular diseases.1[1], 9[2], 3[3]

Phenotype Driver:

Gene-centric:APOC1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data