Infomap Cluster 8

Metabolite Network

mQTL individually significant in locus
Novel rQTL
Known rQTL

Aggregated Cluster Evidence

Significant GTEx eQTL Colocalization (P-alpha < 5e-5)

Tissue Gene P(alpha) Associated Metabolites
Heart Left Ventricle NFATC3 1.10e-05 1-(1-enyl-stearoyl)-gpe (p-18:0)*lignoceroyl sphingomyelin (d18:1/24:0)n-palmitoyl-sphinganine (d18:0/16:0)sphingomyelin (d18:1/20:0, d16:1/22:0)*
Whole Blood SLC7A6 1.54e-05 1-(1-enyl-stearoyl)-gpe (p-18:0)*lignoceroyl sphingomyelin (d18:1/24:0)n-palmitoyl-sphinganine (d18:0/16:0)sphingomyelin (d18:1/20:0, d16:1/22:0)*
Thyroid PLA2G15 3.73e-05 1-(1-enyl-stearoyl)-gpe (p-18:0)*lignoceroyl sphingomyelin (d18:1/24:0)n-palmitoyl-sphinganine (d18:0/16:0)sphingomyelin (d18:1/20:0, d16:1/22:0)*

Genomic Context

Displaying 7 SNPs on Chr 19 for Cluster 8.

Novel rQTL (▲)
Known rQTL (▲)

Cluster Summary

72

Metabolite Ratios (rQTLs)

34

Total Unique Metabolites

0

Unnamed Metabolites

Ratios in Cluster 8

Ratio Name Novel in Cluster Driven By
1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)* to sphingomyelin (d18:1/19:0, d19:1/18:0)* Yes
1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* to sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0) No
1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* to sphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0)* No
1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1) to palmitoyl sphingomyelin (d18:1/16:0) No
1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1) to sphingomyelin (d18:1/20:0, d16:1/22:0)* No
1-(1-enyl-stearoyl)-gpe (p-18:0)* to sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0) Yes
1-(1-enyl-stearoyl)-gpe (p-18:0)* to sphingomyelin (d18:1/19:0, d19:1/18:0)* Yes
1-(1-enyl-stearoyl)-gpe (p-18:0)* to sphingomyelin (d18:1/20:0, d16:1/22:0)* No
1-(1-enyl-stearoyl)-gpe (p-18:0)* to sphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0)* Yes
1-palmitoyl-2-linoleoyl-gpc (16:0/18:2) to lignoceroyl sphingomyelin (d18:1/24:0) Yes
1-palmitoyl-2-linoleoyl-gpi (16:0/18:2) to lignoceroyl sphingomyelin (d18:1/24:0) Yes
1-palmitoyl-2-linoleoyl-gpi (16:0/18:2) to tricosanoyl sphingomyelin (d18:1/23:0)* Yes
1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to sphingomyelin (d18:1/20:0, d16:1/22:0)* No
behenoyl sphingomyelin (d18:1/22:0)* to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* No
cholesterol to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* No
hydroxypalmitoyl sphingomyelin (d18:1/16:0(oh))** to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* No
lignoceroyl sphingomyelin (d18:1/24:0) to 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpc (p-16:0/20:4)* Yes
lignoceroyl sphingomyelin (d18:1/24:0) to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)* Yes
lignoceroyl sphingomyelin (d18:1/24:0) to 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)* Yes
lignoceroyl sphingomyelin (d18:1/24:0) to 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)* Yes
lignoceroyl sphingomyelin (d18:1/24:0) to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* No
lignoceroyl sphingomyelin (d18:1/24:0) to 1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1) No
lignoceroyl sphingomyelin (d18:1/24:0) to 1-(1-enyl-stearoyl)-gpe (p-18:0)* Yes
lignoceroyl sphingomyelin (d18:1/24:0) to 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* Yes
lignoceroyl sphingomyelin (d18:1/24:0) to 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* Yes
lignoceroyl sphingomyelin (d18:1/24:0) to 1-stearoyl-2-linoleoyl-gpi (18:0/18:2) Yes
lignoceroyl sphingomyelin (d18:1/24:0) to 1-stearoyl-2-oleoyl-gpi (18:0/18:1)* Yes
lignoceroyl sphingomyelin (d18:1/24:0) to 1-stearoyl-gpe (18:0) Yes
lignoceroyl sphingomyelin (d18:1/24:0) to n-palmitoyl-sphinganine (d18:0/16:0) Yes
n-palmitoyl-sphinganine (d18:0/16:0) to sphingomyelin (d18:1/19:0, d19:1/18:0)* Yes
oleoyl-linoleoyl-glycerol (18:1/18:2) [2] to sphingomyelin (d18:1/20:0, d16:1/22:0)* No
palmitoyl dihydrosphingomyelin (d18:0/16:0)* to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)* Yes
palmitoyl dihydrosphingomyelin (d18:0/16:0)* to 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)* Yes
palmitoyl dihydrosphingomyelin (d18:0/16:0)* to 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)* Yes
palmitoyl dihydrosphingomyelin (d18:0/16:0)* to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* No
palmitoyl dihydrosphingomyelin (d18:0/16:0)* to 1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1) No
palmitoyl dihydrosphingomyelin (d18:0/16:0)* to 1-(1-enyl-stearoyl)-gpe (p-18:0)* Yes
palmitoyl dihydrosphingomyelin (d18:0/16:0)* to 1-stearoyl-2-linoleoyl-gpi (18:0/18:2) Yes
palmitoyl dihydrosphingomyelin (d18:0/16:0)* to 1-stearoyl-2-oleoyl-gpi (18:0/18:1)* Yes
palmitoyl dihydrosphingomyelin (d18:0/16:0)* to n-palmitoyl-sphinganine (d18:0/16:0) Yes
palmitoyl sphingomyelin (d18:1/16:0) to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* No
palmitoyl sphingomyelin (d18:1/16:0) to 1-(1-enyl-stearoyl)-gpe (p-18:0)* Yes
palmitoyl-sphingosine-phosphoethanolamine (d18:1/16:0) to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* No
sphingomyelin (d18:1/14:0, d16:1/16:0)* to sphingomyelin (d18:1/20:0, d16:1/22:0)* No
sphingomyelin (d18:1/14:0, d16:1/16:0)* to sphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0)* Yes
sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0) to 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)* Yes
sphingomyelin (d18:1/20:0, d16:1/22:0)* to 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)* No
sphingomyelin (d18:1/20:0, d16:1/22:0)* to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* No
sphingomyelin (d18:1/20:0, d16:1/22:0)* to linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]* No
sphingomyelin (d18:1/20:0, d16:1/22:0)* to n-palmitoyl-sphinganine (d18:0/16:0) No
sphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0)* to 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)* Yes
sphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0)* to n-palmitoyl-sphinganine (d18:0/16:0) Yes
sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)* to 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)* Yes
sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)* to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* No
sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)* to 1-(1-enyl-stearoyl)-gpe (p-18:0)* Yes
sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)* to 1-stearoyl-gpe (18:0) Yes
stearoyl sphingomyelin (d18:1/18:0) to 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)* Yes
stearoyl sphingomyelin (d18:1/18:0) to 1-(1-enyl-stearoyl)-gpe (p-18:0)* Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)* Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)* Yes N/A
tricosanoyl sphingomyelin (d18:1/23:0)* to 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)* Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* No
tricosanoyl sphingomyelin (d18:1/23:0)* to 1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1) No
tricosanoyl sphingomyelin (d18:1/23:0)* to 1-(1-enyl-stearoyl)-gpe (p-18:0)* Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to 1-oleoylglycerol (18:1) Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2) Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to 1-stearoyl-2-linoleoyl-gpi (18:0/18:2) Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to 1-stearoyl-2-oleoyl-gpi (18:0/18:1)* Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to 1-stearoyl-gpe (18:0) Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to n-palmitoyl-sphinganine (d18:0/16:0) Yes